Norelgestromin is a third-generation synthetic progestin, making it a pretty recent addition to the collection of contraceptive hormones. It was first made available in 20021, and is used in the hormonal patch alongside ethinyl estradiol, a synthetic oestrogen.
How does it work?
When used in combination with ethinyl estradiol, norelgestromin inhibits ovulation and thickens your cervical mucus, making it harder for sperm to enter your uterus2.
What is it in?
- Hormonal patch – Evra
Is it androgenic?
Yes – it’s Androgenic
What are the side effects?
As Norelgestromin is only available to take in combination with ethinyl estradiol, it’s impossible to say which side effects are caused by which hormone. Side effects reported as common for Norelgestromin taken alongside ethinyl estradiol are3:
- Breast abnormalities
- Gastrointestinal discomfort
- Increased risk of infection
- Malaise (general feeling of unwellness)
- Menstrual cycle irregularities
- Altered mood
- Muscle spasms
- Skin reactions
- Uterine cramps
- Vaginal haemorrhage (heavy bleed)
- Vulvovaginal disorders
- Annual reports in Medicinal Chemistry. Elsevier. 2012. Volume 47. p620
- Chapter 5 Birth Control. Mosby’s Guide to Women’s Health: A Handbook for Health Professionals. Mosby Elsevier. 2007. p30 <https://doi.org/10.1016/B978-032304601-5.50039-3> [Accessed 13 August 2020]
- Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press <https://bnf.nice.org.uk/drug/ethinylestradiol-with-norelgestromin.html> [Accessed on 13 August 2020]