As an original, first-generation synthetic progestin, Medroxyprogesterone Acetate has a long and varied history. Now used only in some contraceptive Injections, in the past it played the starring role in hormone therapy for menopausal women, other forms of contraception and even as a treatment for some cancers1.

Controversially, Medroxyprogesterone Acetate was historically used as a form of male chemical castration, and is still used as punishment for some sexual behaviours that are deemed criminal by certain jurisdictions2

What is it used in?

Contraceptive injection

Is it androgenic?

Yes, but the amount varies.

What are the side effects?

The following side effects have been noted as common or very common when Medroxyprogesterone Acetate is taken as an injection1


  1. Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press <> [Accessed on 13 August 2020]
  2. Giordano K. The chemical knife. Salon Health & Beauty. 1 March 2000. Available from: <> [Accessed 13 August 2020]

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